Excitatory amino acid transporter 4

SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,022,990 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,650,599 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; endothelial cell; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; skin of thigh; ; cerebellar vermis; ; nucleus accumbens; ; oocyte; ; caudate nucleus;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; dorsomedial hypothalamic nucleus; ; lumbar subsegment of spinal cord; ; ventromedial nucleus; ; inferior colliculi; ; superior colliculus; ; dentate gyrus of hippocampal formation granule cell; ; lateral hypothalamus; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-aspartate transmembrane transporter activity; symporter activity; L-glutamate transmembrane transporter activity; amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; metal ion binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; intermediate filament cytoskeleton; integral component of plasma membrane; plasma membrane; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	chemical synaptic transmission; regulation of membrane potential; ion transport; glutamate secretion; aspartate transmembrane transport; L-glutamate transmembrane transport; L-glutamate import across plasma membrane; amino acid transport; L-aspartate transmembrane transport; neurotransmitter uptake; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6511
	20513
	ENSG00000105143
	ENSMUSG00000005357
	P48664
	O35544
NM_001272087; NM_001272088; NM_005071; NM_001384669; NM_001384670;
	NM_001384671
	NM_009200
	NP_001259016; NP_001259017; NP_005062
	NP_033226
	Wikidata
View/Edit Human	View/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.^[5]^[6]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105143 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005357 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
^ ^a ^b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. S2CID 42347750.
Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. Bibcode:2001Natur.410...89J. doi:10.1038/35065091. PMID 11242047. S2CID 4381210.
Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. S2CID 30779935.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105143 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005357 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".

[pmid7791878-6] Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

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References

Further reading