USSC
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USSC may refer to:
Government
- United States Supreme Court, the highest federal court of the United States
 - United States Sentencing Commission, an agency responsible for stating the sentencing guidelines for the United States federal courts
 
Military
- United States Space Command, a unified combatant command of the U.S. Armed Forces
 - United States Sanitary Commission, a relief agency that supported injured soldiers of the U.S. Army during the American Civil War
 
Other uses
- United States Steel Corporation
 - United States Studies Centre, a non-profit organization headquartered at University of Sydney
 - United States Surgical Corporation, a former manufacturer of medical devices