Route 59 (disambiguation)
Route 59 may refer to:
- Route 59 (MTA Maryland), a bus route in Baltimore, Maryland and its suburbs
- London Buses route 59
- Melbourne tram route 59
- SEPTA Route 59, a trackless trolley in Northeast Philadelphia
- Route 59 station, a Metra train station along the BNSF Line on the border of Aurora, Illinois and Naperville, Illinois