PKS
PKS may refer to:
- Pammal K. Sambandam, a 2002 Tamil language comedy film
 - Państwowa Komunikacja Samochodowa, Polish transport organization
 - Parkstone railway station, station code
 - Phi Kappa Sigma International Fraternity
 - Parkes Catalogue of Radio Sources, an astronomical catalogue
 - Polyketide synthases, enzymes
 - Prosperous Justice Party (Partai Keadilan Sejahtera), Indonesia
 - Serbian Chamber of Commerce
 - Pallister-Killian syndrome, a rare genetic disorder which is caused by additional 4 copies of the short arm of chromosome 12