MOST
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MOST may refer to:
Organizations
- MOST (Croatia), a political party in Croatia founded in 2012
 - Milton J. Rubenstein Museum of Science and Technology, a museum in Syracuse, New York, US
 - Ministry of Science and Technology, a ministry or other government agency
 - MOST (Association, Serbia) a Non-governmental Citizen's association from Serbia
 - Music & Opera Singers Trust, an opera and classic music organisation in Australia that created the Opera Awards
 - Management of Social Transformations, a program of the UNESCO
 
Science and technology
- Maynard Operation Sequence Technique, a work measurement system
 - Media Oriented Systems Transport, an electronic bus type architecture for on-board audio-visual devices, primarily in automobiles
 - Microvariability and Oscillations of STars telescope, a stellar photometric monitoring satellite built by Canada
 - Molonglo Observatory Synthesis Telescope, a radio telescope in Australia
 - MOST (ATM Network) a defunct network of bank Automatic Teller Machines on the East Coast of the United States