List of Major League Baseball career losses leaders

In the sport of baseball, a loss is a statistic credited to the pitcher of the losing team responsible for the run that gives the opposing team the lead with which the game is won (the go-ahead run). The losing pitcher is the pitcher responsible for the go-ahead run to reach base for a lead that the winning team never relinquishes. If a pitcher allows a run that gives the opposing team the lead, his team comes back to lead or tie the game, and then the opposing team regains the lead against a subsequent pitcher, the earlier pitcher does not get the loss.
Cy Young holds the MLB loss record with 316; Pud Galvin is second with 308. Young and Galvin are the only players to earn 300 or more losses.
Key
| Rank | Rank amongst leaders in career games lost. A blank field indicates a tie. |
| Player | Name of player. |
| L | Total career games lost |
| * | Denotes elected to National Baseball Hall of Fame. |
|---|
List
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- Stats updated as of July 4, 2025.
| Rank | Player | L |
|---|---|---|
| 1 | Cy Young* | 316 |
| 2 | Pud Galvin* | 308 |
| 3 | Nolan Ryan* | 292 |
| 4 | Walter Johnson* | 279 |
| 5 | Phil Niekro* | 274 |
| 6 | Gaylord Perry* | 265 |
| 7 | Don Sutton* | 256 |
| 8 | Jack Powell | 254 |
| 9 | Eppa Rixey* | 251 |
| 10 | Bert Blyleven* | 250 |
| 11 | Bobby Mathews | 248 |
| 12 | Robin Roberts* | 245 |
| Warren Spahn* | 245 | |
| 14 | Steve Carlton* | 244 |
| Early Wynn* | 244 | |
| 16 | Jim Kaat* | 237 |
| 17 | Frank Tanana | 236 |
| 18 | Gus Weyhing | 232 |
| 19 | Tommy John | 231 |
| 20 | Bob Friend | 230 |
| Ted Lyons* | 230 | |
| 22 | Greg Maddux* | 227 |
| 23 | Ferguson Jenkins* | 226 |
| 24 | Tim Keefe* | 225 |
| Red Ruffing* | 225 | |
| 26 | Bobo Newsom | 222 |
| 27 | Tony Mullane | 220 |
| 28 | Jack Quinn | 218 |
| 29 | Sad Sam Jones | 217 |
| 30 | Charlie Hough | 216 |
| 31 | Jim McCormick | 214 |
| 32 | Red Faber* | 213 |
| 33 | Paul Derringer | 212 |
| Chick Fraser | 212 | |
| Burleigh Grimes* | 212 | |
| 36 | Mickey Welch* | 210 |
| 37 | Jerry Koosman | 209 |
| Jamie Moyer | 209 | |
| 39 | Grover Cleveland Alexander* | 208 |
| Kid Nichols* | 208 | |
| 41 | Tom Seaver* | 205 |
| Vic Willis* | 205 | |
| 43 | Joe Niekro | 204 |
| Jim Whitney | 204 | |
| 45 | Tom Glavine* | 203 |
| 46 | George Mullin | 196 |
| Adonis Terry | 196 | |
| 48 | Claude Osteen | 195 |
| 49 | Eddie Plank* | 194 |
| Charles Radbourn* | 194 |
| Rank | Player | L |
|---|---|---|
| 51 | Dennis Martínez | 193 |
| 52 | Mickey Lolich | 191 |
| Rick Reuschel | 191 | |
| Jerry Reuss | 191 | |
| Tom Zachary | 191 | |
| 56 | Al Orth | 189 |
| 57 | Bartolo Colón | 188 |
| Christy Mathewson* | 188 | |
| 59 | Mel Harder | 186 |
| Mike Morgan | 186 | |
| Jack Morris* | 186 | |
| 62 | Earl Whitehill | 185 |
| 63 | Jim Bunning* | 184 |
| Bullet Joe Bush | 184 | |
| Roger Clemens | 184 | |
| 66 | Larry Jackson | 183 |
| Curt Simmons | 183 | |
| 68 | Danny Darwin | 182 |
| Hooks Dauss | 182 | |
| Waite Hoyt* | 182 | |
| 71 | Murry Dickson | 181 |
| Dutch Leonard | 181 | |
| Rick Wise | 181 | |
| 74 | Lee Meadows | 180 |
| Tim Wakefield | 180 | |
| 76 | Pink Hawley | 179 |
| Dolf Luque | 179 | |
| 78 | John Clarkson* | 178 |
| Wilbur Cooper | 178 | |
| 80 | Bill Dinneen | 177 |
| Liván Hernández | 177 | |
| Rube Marquard* | 177 | |
| 83 | Mike Moore | 176 |
| 84 | Red Donahue | 175 |
| 85 | Doyle Alexander | 174 |
| Bob Gibson* | 174 | |
| Tom Hughes | 174 | |
| Jim Perry | 174 | |
| Amos Rusie* | 174 | |
| 90 | Chuck Finley | 173 |
| 91 | Luis Tiant | 172 |
| 92 | Dennis Eckersley* | 171 |
| Larry French | 171 | |
| 94 | Ted Breitenstein | 170 |
| Camilo Pascual | 170 | |
| 96 | Billy Pierce | 169 |
| 97 | Red Ames | 167 |
| Jim Clancy | 167 | |
| Bert Cunningham | 167 | |
| Red Ehret | 167 |
See also
- Baseball statistics
- List of Major League Baseball career wins leaders
- List of Major League Baseball career games started leaders
- List of Major League Baseball career games finished leaders