Galactose 1-dehydrogenase (NADP+)
| galactose 1-dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.120 | ||||||||
| CAS no. | 37250-51-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a galactose 1-dehydrogenase (NADP+) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction
- D-galactose + NADP+ D-galactono-1,5-lactone + NADPH + H+
Thus, the two substrates of this enzyme are D-galactose and NADP+, whereas its 3 products are D-galactono-1,5-lactone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-galactose:NADP+ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP+), and galactose 1-dehydrogenase (NADP+). This enzyme participates in galactose metabolism.
References
- Cline AL, Hu AS (1965). "The isolation of three sugar dehydrogenases from a psuedomonad". J. Biol. Chem. 240 (11): 4488–92. doi:10.1016/S0021-9258(18)97087-0. PMID 5845847.
- Cline AL, Hu AS (1965). "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. doi:10.1016/S0021-9258(18)97088-2. PMID 5845848.
- Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. doi:10.1016/S0021-9258(18)97089-4. PMID 5845849.
- Schiwara HW, Domagk GF (1968). "Über den Abbau der Desoxyzucker durch Bakterienenzyme, V. Anreicherung und Charakterisierung einer NADP-abhängigen Abequosedehydrogenase aus Pseudomonas putida" [Degradation of deoxysurgars by bacterial enzymes. V. Purification and characterization of an NADP-dependent abequose dehydrogenase from Pseudomonas putida]. Hoppe-Seyler's Z. Physiol. Chem. (in German). 349 (10): 1321–9. doi:10.1515/bchm2.1968.349.2.1321. PMID 4387016.