In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission.
A GABAergic or GABAnergic agent is any chemical that modifies the effects of GABA in the body or brain. Some different classes of GABAergic drugs include agonists, antagonists, modulators, reuptake inhibitors and enzymes.[1]
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References
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| Ionotropic | | GABAATooltip γ-Aminobutyric acid A receptor | 
Positive modulators (abridged; see here for a full list): α-EMTBLAlcohols (e.g., drinking alcohol, 2M2B)Anabolic steroidsAvermectins (e.g., ivermectin)Barbiturates (e.g., phenobarbital)Benzodiazepines (e.g., diazepam)Bromide compounds (e.g., potassium bromide)Carbamates (e.g., meprobamate)CarbamazepineChloraloseChlormezanoneClomethiazoleDihydroergolines (e.g., ergoloid (dihydroergotoxine))EtazepineEtifoxineFenamates (e.g., mefenamic acid)Flavonoids (e.g., apigenin, hispidulin)FluoxetineFlupirtineImidazoles (e.g., etomidate)Kava constituents (e.g., kavain)LanthanumLoreclezoleMonastrolNeuroactive steroids (e.g., allopregnanolone, cholesterol, THDOC)NiacinNiacinamideNonbenzodiazepines (e.g., β-carbolines (e.g., abecarnil), cyclopyrrolones (e.g., zopiclone), imidazopyridines (e.g., zolpidem), pyrazolopyrimidines (e.g., zaleplon))NorfluoxetinePetrichloralPhenols (e.g., propofol)PhenytoinPiperidinediones (e.g., glutethimide)PropanididPyrazolopyridines (e.g., etazolate)Quinazolinones (e.g., methaqualone)Retigabine (ezogabine)ROD-188Skullcap constituents (e.g., baicalin)StiripentolSulfonylalkanes (e.g., sulfonmethane (sulfonal))TopiramateValerian constituents (e.g., valerenic acid)Volatiles/gases (e.g., chloral hydrate, chloroform, diethyl ether, paraldehyde, sevoflurane)
 Negative modulators: 1,3M1B3M2B11-Ketoprogesterone17-Phenylandrostenolα3IAα5IA (LS-193,268)β-CCBβ-CCEβ-CCMβ-CCPβ-EMGBLAnabolic steroidsAmilorideAnisatinβ-Lactams (e.g., penicillins, cephalosporins, carbapenems)BasmisanilBemegrideBicyclic phosphates (TBPS, TBPO, IPTBO)BIDNBilobalideBupropionCHEBChlorophenylsilatraneCicutoxinCloflubicyneCyclothiazideDHEADHEA-SDieldrin(+)-DMBBDMCMDMPCEBOBEtbicyphatFG-7142 (ZK-31906)Fiproles (e.g., fipronil)Flavonoids (e.g., amentoflavone, oroxylin A)FlumazenilFluoroquinolones (e.g., ciprofloxacin)FlurothylFurosemideGolexanoloneIomazenil (123I)IPTBOIsopregnanolone (sepranolone)L-655,708LaudanosineLindaneMaxiPostMorphineMorphine-3-glucuronideMRK-016NaloxoneNaltrexoneNicardipineNonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide)OenanthotoxinPentylenetetrazol (pentetrazol)PhenylsilatranePicrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin)Pregnenolone sulfatePropybicyphatPWZ-029RadequinilRo 15-4513Ro 19-4603RO4882224RO4938581SarmazenilSCSSuritozoleTB-21007TBOBTBPSTCS-1105TerbequinilTETSThujoneU-93631ZincZK-93426
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 | GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor |  | 
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| Metabotropic | | GABABTooltip γ-Aminobutyric acid B receptor | 
Negative modulators: Compound 14
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See alsoReceptor/signaling modulators GABAA receptor positive modulators GABA metabolism/transport modulators 
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